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. Author manuscript; available in PMC: 2021 Jan 28.
Published in final edited form as: Paediatr Perinat Epidemiol. 2020 Jun 2;35(1):92–97. doi: 10.1111/ppe.12690

TABLE 2.

Escala Abreviada de Desarrollo, version 1a (EAD-1) screener results at 20–30 mo of age among children postnatally infected with ZIKVb (N = 60), Colombia, September-November 2017

Developmental domains Without adverse neurologic, eye, or hearing outcomes (N = 51) With adverse neurologic, eye, or hearing outcomes (N = 9c)
Gross motor (N = 51) (N = 9)
 Alertd 0 (0%) 1 (11.1%)
Fine motor (N = 51) (N = 9)
 Alertd 2 (3.9%) 1 (11.1%)
Hearing and language (N = 47e) (N = 9)
 Alertd 6 (12.8%) 2 (22.2%)
Personal-social (N = 50e) (N = 9)
 Alertd 3 (6.0%) 1 (11.1%)
a

The EAD-1 is a standardised, validated developmental screening tool in Colombia.

b

Participants were laboratory-confirmed with ZIKV infection by rRT-PCR within one week of symptom onset at 1–12 mo of age.

c

One child with hypotonia also had a diagnosis of Down syndrome; the other child with hypotonia also had a diagnosis of sensorineural hearing loss; three children had unknown hearing loss; and four children had an abnormal eye finding. The child with abnormal retinal scarring also had reported congenital toxoplasmosis.

d

An “alert” was based on cut points defined in the EAD-1 manual.

e

Children whose domain score could not be calculated due to incorrect EAD-1 application were excluded.