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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Neurotoxicology. 2020 Oct 13;81:147–160. doi: 10.1016/j.neuro.2020.10.005

Figure 4. Harmane modulates mitochondrial morphology in neuromelanin forming SH-SY5Y cells.

Figure 4.

A-D. MitoTracker staining shows mitochondrial morphology in EV-transfected control (A), EV-transfected HAR treated (C), TYR-transfected control (B) and TYR-transfected HAR-treated (D) SH-SY5Y cells. Scale bar, 20 μm. E. Total mitochondrial content and F. mitochondrial circularity (indicative of mitochondrial fragmentation) was determined using imageJ and values were converted to arbitrary numbers (representative examples shown in with arrows and 3x insets). Data expressed as mean ± S.E.M. *p<0.05, ***p<0.001 and ****p<0.0001 vs EV control group; # #p<0.01 vs EV HAR-treated cells; and Δ Δ Δp<0.001 vs EV HAR-treated cells.