Table 1.
Biodistribution of 18F-mFBG 4 h after injection of mice bearing Kelly xenografts, pre-treated with AZD2014 (25 mg/kg/day) or vehicle control (DMSO 10%, PEG400 90%) for 3 days.
| Kelly | 18F-mFBG biodistribution 4 h p.i. (mean %ID/g ± SD) | |
|---|---|---|
| Vehicle | AZD2014 (25 mg/kg/day) | |
| N = | 3 | 3 |
| Blood | 0.22 ± 0.05 | 0.19 ± 0.03 |
| Heart | 6.34 ± 1.41 | 4.22 ± 0.85 |
| Lungs | 1.52 ± 0.22 | 1.31 ± 0.39 |
| Kidney | 1.11 ± 0.47 | 0.97 ± 0.17 |
| Spleen | 3.77 ± 0.82 | 4.58 ± 0.77 |
| Liver | 2.37 ± 0.71 | 2.08 ± 0.45 |
| Pancreas | 1.26 ± 0.28 | 1.25 ± 0.21 |
| Tumour | 0.39 ± 0.13 | 0.74 ± 0.25 |
| Bone | 1.43 ± 0.83 | 0.99 ± 0.07 |
| Small intestine | 6.57 ± 1.12 | 7.30 ± 1.11 |
| Muscle | 0.74 ± 0.23 | 0.64 ± 0.17 |
| Brown adipose | 5.84 ± 2.44 | 7.20 ± 0.88 |
| Tumour:blood | 1.75 ± 0.29 | 4.16 ± 1.89 |
| Tumour:muscle | 0.53 ± 0.01 | 1.23 ± 0.61 |
Data are presented as mean ± SD, n = 3 per group.