Table 2.

Biodistribution of ¹⁸F-mFBG 4 h after injection of mice bearing SK-N-BE(2)C xenografts, pre-treated with AZD2014 (20 mg/kg/day) or vehicle control (DMSO 10%, PEG400 90%) for 1, 3 or 7 days.

SK-N-BE(2)C	18F-mFBG biodistribution 4 h p.i. (%ID/g)
	1 day vehicle	1 day AZD2014 (20 mg/kg/day)	3 day vehicle	3 Day AZD2014 (20 mg/kg/day)	7 day vehicle	7 day AZD2014 (20 mg/kg/day)
N =	3	3	3	3	3	3
Blood	0.18 ± 0.02	0.18 ± 0.04	0.18 ± 0.08	0.16 ± 0.02	0.17 ± 0.06	0.32 ± 0.14
Heart	4.38 ± 1.68	4.34 ± 2.38	3.64 ± 0.89	3.20 ± 0.43a	5.87 ± 2.80	4.17 ± 1.63
Lungs	1.22 ± 0.37	1.27 ± 0.68	1.15 ± 0.23	1.04 ± 0.12	1.86 ± 0.64	1.33 ± 0.36
Kidney	0.79 ± 0.36	0.98 ± 0.04	1.13 ± 0.47	0.89 ± 0.13	1.09 ± 0.16	1.02 ± 0.15
Spleen	3.19 ± 0.63	2.93 ± 0.82	2.08 ± 1.29	2.27 ± 1.06	1.75 ± 0.67	1.64 ± 0.46
Liver	1.94 ± 0.30	1.63 ± 0.69	1.96 ± 0.02	1.74 ± 0.23	2.15 ± 0.30	2.64 ± 0.46
Pancreas	1.01 ± 0.18	1.09 ± 0.42	1.25 ± 0.51	1.29 ± 0.51	2.81 ± 1.72	3.08 ± 1.80
Tumour	2.76 ± 1.14	3.29 ± 1.01	2.39 ± 0.10	3.95 ± 1.53	2.17 ± 1.01	2.61 ± 1.19
Small intestine	4.50 ± 0.24b	4.79 ± 1.21	5.32 ± 0.11	4.88 ± 1.28	6.22 ± 0.35	6.87 ± 1.86
Muscle	0.60 ± 0.13	0.59 ± 0.16	0.53 ± 0.19	0.55 ± 0.09	0.67 ± 0.07	0.75 ± 0.02
Brown adipose	5.14 ± 0.38b	5.47 ± 0.45b	5.15 ± 0.78b	5.32 ± 1.51b	6.08 ± 2.45	8.08 ± 0.72
Bone	4.98 ± 2.18c	4.55 ± 2.15c	1.64 ± 0.45	2.42 ± 2.57	1.13 ± 0.20	0.63 ± 0.54
Tumour:blood	15.27 ± 5.32	17.72 ± 2.35	14.47 ± 4.61	23.76 ± 6.20	15.55 ± 13.55	8.06 ± 2.57
Tumour:muscle	4.44 ± 0.94	5.74 ± 1.77	4.89 ± 1.48	7.06 ± 1.79	3.36 ± 1.90	3.50 ± 1.62

Data are presented as mean ± SD, n = 3 per group.

a = p < 0.05 compared to 7-day vehicle group of the same tissue.

b = p < 0.05 compared to 7-day AZD2014 group of the same tissue.

c = p < 0.05 compared to 3-day and 7-day groups of the same tissue.