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. 2020 Dec 1;10:20915. doi: 10.1038/s41598-020-77345-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of ASP5878 in a patient-specific iPSC disease model for ACH. (a) Scheme showing the chondrogenic differentiation of ACH-iPSCs. After chondrogenic differentiation, the cells were transferred to suspension culture. ASP5878 or vehicle was added from day 15. Particles were subjected to analysis on day 84. ES, embryonic stem cell medium; MD mesodermal medium, Ch chondrogenic medium. (b) Results of a real-time RT-PCR expression analysis of marker genes. Three out of four independent experiments showed similar results. Error bars denote the means ± s.d. *P < 0.05; **P < 0.01 by the t-test. (c) Histology of the particles. Scale bars, 300 μm.