Table 3.
Association of prenatal phthalate metabolite with asthma and wheeze outcomes at 4–6 years of age in combined CANDLE/TIDES cohort.
| Odds Ratio (95% Confidence Interval) | ||
|---|---|---|
| Unadjusted | Adjusted | |
| Current Wheeze | ||
| MEP | 1.08 (1.02, 1.15) | 1.02 (0.94, 1.10) |
| MBP | 1.16 (1.04, 1.30) | 1.00 (0.87, 1.15) |
| MiBP | 1.05 (0.93, 1.18) | 0.93 (0.81, 1.07) |
| MBzP | 1.05 (0.96, 1.14) | 0.92 (0.84, 1.01) |
| MCPP | 1.03 (0.94, 1.14) | 1.04 (0.93, 1.17) |
| MCOP | 0.93 (0.87, 1.00) | 1.01 (0.92, 1.11) |
| MCNP | 0.87 (0.80, 0.94) | 0.94 (0.84, 1.04) |
| ΣDEHP | 0.93 (0.83, 1.04) | 0.88 (0.77, 1.00) |
| MEHP | 0.93 (0.86, 1.01) | 0.91 (0.84, 0.99) |
| MEHHP | 0.95 (0.88, 1.03) | 0.93 (0.85, 1.02) |
| MEOHP | 0.93 (0.84, 1.02) | 0.87 (0.77, 0.98) |
| MECPP | 0.95 (0.85, 1.06) | 0.91 (0.80, 1.03) |
| Current Asthma | ||
| MEP | 1.13 (1.06, 1.20) | 1.06 (0.97, 1.15) |
| MBP | 1.22 (1.08, 1.38) | 1.05 (0.89, 1.23) |
| MiBP | 1.10 (0.97, 1.25) | 0.98 (0.83, 1.15) |
| MBzP | 1.09 (0.99, 1.21) | 0.95 (0.84, 1.06) |
| MCPP | 0.99 (0.90, 1.09) | 1.02 (0.90, 1.15) |
| MCOP | 0.89 (0.82, 0.96) | 0.98 (0.88, 1.09) |
| MCNP | 0.81 (0.74, 0.89) | 0.91 (0.81, 1.03) |
| ΣDEHP | 0.97 (0.86, 1.09) | 0.91 (0.79, 1.05) |
| MEHP | 0.90 (0.82, 0.99) | 0.88 (0.80, 0.97) |
| MEHHP | 0.97 (0.88, 1.07) | 0.95 (0.86, 1.05) |
| MEOHP | 0.97 (0.86, 1.08) | 0.91 (0.79, 1.05) |
| MECPP | 0.99 (0.88, 1.12) | 0.96 (0.84, 1.10) |
| Ever Asthma | ||
| MEP | 1.10 (1.03, 1.18) | 1.04 (0.95, 1.14) |
| MBP | 1.21 (1.07, 1.38) | 1.06 (0.91, 1.23) |
| MiBP | 1.08 (0.95, 1.23) | 0.96 (0.83, 1.12) |
| MBzP | 1.05 (0.95, 1.17) | 0.91 (0.81, 1.02) |
| MCPP | 1.03 (0.93, 1.14) | 1.03 (0.91, 1.16) |
| MCOP | 0.94 (0.87, 1.01) | 1.01 (0.91, 1.12) |
| MCNP | 0.86 (0.79, 0.94) | 0.93 (0.82, 1.06) |
| ΣDEHP | 0.94 (0.83, 1.05) | 0.89 (0.78, 1.02) |
| MEHP | 0.93 (0.85, 1.01) | 0.90 (0.82, 0.98) |
| MEHHP | 0.96 (0.89, 1.05) | 0.95 (0.87, 1.05) |
| MEOHP | 0.93 (0.83, 1.04) | 0.89 (0.78, 1.01) |
| MECPP | 0.96 (0.85, 1.08) | 0.92 (0.81, 1.05) |
Values below limit of detection (LOD) are imputed as LOD/√2. Phthalate concentrations are corrected for specific gravity and log-transformed. Robust standard errors were used. Adjusted estimates are adjusted for maternal age, maternal race, maternal ethnicity, maternal education, prenatal smoking, pre-pregnancy BMI, maternal history of asthma, child sex, year of child’s birth and study site. Odds ratios are reported per 2-fold increase in phthalate concentration.