Fig. 7. Hi-C and Repli-Seq data demonstrate the same replication timing for cohesin depleted and non-depleted control cells.

a Contact matrices of chromosome 8 at 500 kb resolution along with the corresponding Repli-Seq early-to-late (E/L) ratio tracks at 50 kb resolution and the first eigenvectors of the Hi-C matrices corresponding to A/B compartmentalization. Replication timing along the genome is conserved, as shown by the correspondence of the untreated and auxin-treated Repli-Seq tracks. In addition, the correspondence between replication timing and genome compartmentalization (as indicated by the plaid pattern in the Hi-C map and the first eigenvector of the Hi-C matrices) is preserved after auxin treatment. b Scatter plot of replication timing (percentile of E/L ratio) in RAD21-mAC cells before (y-axis) and after (x-axis) auxin treatment.