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. 2020 Dec 1;11:6147. doi: 10.1038/s41467-020-19880-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a MNZ is internalized by both G. vaginalis (Gv) and L. iners (Li) at rates k_int-GV and k_int-LI, cells are proliferating at k_grow-GV and k_grow-LI and MNZ inhibits growth by k_kill-GV and k_kill-LI. For Gv, a potential mechanism of MNZ resistance is the bacterial-mediated interactions to the drug leading to the formation of metabolites (k_met). b Sensitivity of Gv growth with 500 μg/ml MNZ when parameters directly related to Gv growth are varied 0.001× to 1000× baseline values. Percent maximal growth refers to the final cell count compared to the carrying capacity of the culture, or the maximum cell density the unperturbed culture can reach at 48 h based on initial cell density. c Sensitivity of Gv growth with 500 μg/ml MNZ when parameters related to Li survival are varied 0.001× to 1000× baseline values. d Percent maximal growth of Gv (left) and Li (right) when the initial ratio of Gv to Li is varied with 500 μg/ml MNZ treatment. e Percent maximal growth of Gv when MNZ internalization rate of Li is varied at three different population compositions with 500 μg/ml MNZ treatment.