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. 2020 Dec 1;11:6147. doi: 10.1038/s41467-020-19880-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Surface plot illustrates model predictions for proportion of Li relative to Gv 48 h at different starting Gv:Li ratios (x-axis) and at different doses of MNZ (y-axis). Experimental validation was performed in in vitro co-cultures of Li and Gv (n = 18 independent, biological replicates for each ratio) and is plotted on the surface, with mean ± SD represented by nodes and vertical lines. b Phase diagram of microbial growth dynamics 48 h after exposure to various MNZ doses, dots indicate experimental conditions evaluated. There are four possibilities: Both Gv and Li populations are increased after treatment, both Gv and Li populations are decreased, only the Gv population is increased and only the Li population is increased. Pie charts indicate the fraction of experimental samples that agree with the predicted trends (right).