Table 1:
Frequently encountered low-function alleles in TPMT and NUDT15.
Data for the frequency of NUDT15 variant alleles in African Americans is unavailable at this time. Adapted from current Clinical Pharmacogenetics Implementation Consortium guidelines.(21)
| Gene/Haplotype | rsID | Allele Frequency | |||
|---|---|---|---|---|---|
| European | African American | Hispanic | East Asian | ||
| TPMT | |||||
| *3A | rs1800460, rs1142345 |
3.4% | 0.8% | 4.2% | <0.1% |
| *3C | rs1142345 | 0.5% | 2.4% | 0.6% | 1.6% |
| *2 | rs267607275 | 0.2% | 0.5% | 0.4% | <0.1% |
| Other non-reference | Various | 0.6% | 3.9% | 0.6% | 0.4% |
| NUDT15 | |||||
| *2 | rs869320766, rs116855232 |
<0.1% | 3.7% | 3.5% | |
| *3 | rs116855232 | 0.2% | 0.8% | 6.1% | |
| *9 | rs746071566 | <0.1% | <0.1% | <0.1% | |