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. 2020 Nov 27;13:12255–12268. doi: 10.2147/OTT.S263998

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© 2020 Tao et al.

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Invasion assays of MCF-10A and MCF-7 cells transfected with Neg. siRNA and MRPL13 siRNA. The MRPL13 siRNA group showed a measurable blocking effect on cell invasion in both cell lines. The numbers of cells invading into the lower surface of the filter were counted, and a significant difference was observed (A, B; *P < 0.05). Columns, mean; bars, SD; Expression of vascular endothelial growth factor A (VEGFA), matrix metalloproteinase 2 (MMP-2), and MMP-9in MRPL13-depleted MCF-10A and MCF-7 cells. (C) Western blotting and (D) real-time PCR analysis showed the expression changes after silencing MRPL13 in MCF-10A and MCF-7 cells. The expression levels of VEGFA, MMP-2, and MMP-9 were explored. (Columns, mean; bars, SD. *P < 0.05).