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. 2020 Nov 18;23(12):101820. doi: 10.1016/j.isci.2020.101820

Figure 6.

Figure 6

Knockdown of Auts2 in PCs Impairs CF Synapse Elimination and PF Synaptic Transmission

(A) Sample traces of CF-EPSCs (left) and frequency distributions of the number of CFs innervating each PC (right) for Auts2-KD (blue) and control (white) PCs during P21-P30. n = 37 cells, 3 mice for control and n = 33 cells, 3 mice for Auts2 KD.

(B) Normal paired-pulse ratio of CF-EPSCs measured at increasing inter-stimulus intervals in control and Auts2-KD PCs at P20-30 (left, representative traces; right, summary plots). n = 13 cells, 3 mice for control and n = 26 cells, 3 mice for Auts2 KD.

(C) Impaired input-output relationship of PF-EPSCs in Auts2-KD PCs at P20-30. (left, representative traces; right, summary plots). n = 14 cells, 6 mice for control and n = 17 cells, 6 mice for Auts2 KD.

(D) Impaired paired-pulse ratio of PF-EPSCs in Auts2-KD PCs at P20-30 (left, representative traces; right, summary graph). n = 13 cells, 6 mice for control and n = 16 cells, 6 mice for Auts2 KD. Data are shown as mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, by Mann-Whitney U test in A, two-way ANOVA with Tukey's post hoc analysis in B-D.

See also Figure S15 and Table S1.