Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 1;10:20966. doi: 10.1038/s41598-020-77915-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Oxygen delivery, vasculature resistance and patterns of vasoactive substance activation in experimental groups. Arterial PV group blue circles, n = 5 experiments, venous PV group red triangles, n = 5 experiments. (a,b) Representative experiment data of the HA and PV resistance from Group 0 without Nitroprussiat application. The increased HA resistance resulted in a decreased flow between perfusion day 1 and 3. From perfusion day 4, HA resistance decreased and was accompanied with increased PV resistance and absence of bile flow. (c) Oxygen delivery rate in the PV was higher with arterial PV compared to venous PV. (d,e) Oxygen saturation in the vena cava was higher in arterial PV group compared with venous PV group with no difference in oxygen uptake rate between groups during perfusion. (f) Resistance in arterial PV and venous PV groups controlled with Nitropurssiat. (g–l) Vasoactive substance release at mRNA and protein level without significant difference among experimental groups; (g) Endothelin-1 at mRNA level, (h) Endothelin-1 at protein level in tissue, (i) endothelial NO synthase (eNOS) and (j) inducible NO synthase (iNOS) at mRNA level, (k) NO level in perfusate, (l) heme oxygenase 1 at mRNA level. Superoxide dismutase (SOD) at mRNA (m) and protein (n) levels. P value * < 0.05, ** < 0.01, *** < 0.001. ns not significant.