Fig. 5.

Effects of neonatal hyperoxic exposure on glutathione reductase-sufficient (Gsr-WT) and -deficient (Gsr-KO) mice. (A) H&E-stained lung sections (200x) from PND14 Gsr-WT and Gsr-KO neonates exposed to room air (FiO₂ 0.21) or hyperoxia (FiO₂ 0.85) for 14 d (PND0-14). Characteristic alveolar simplification is present in hyperoxia-exposed Gsr-WT mice while evidence of persistent alveolar epithelial dysplasia remains in Gsr-KO mice after hyperoxia exposure. (B) Independent effects of and an interaction between hyperoxia and genotype on alveolar number and perimeter. Data are expressed as mean +SEM (n=3–5). *p < 0.05 vs Gsr-WT/Room Air. **p < 0.05 vs Gsr-KO/Room Air. Bars = 50 μm.