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. 2020 Nov 13;38:101797. doi: 10.1016/j.redox.2020.101797

Table 3.

Representative glutathione reductase (Gsr)-dependent lung genes at postnatal day 56 (PND56) after neonatal hyperoxia exposure.

RefSeq ID p aFC WT aFC KO ¶FD Gene Symbol Gene Title
NM_001177713 0.00457 −1.73 2.26 4.13 Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1
NM_001166627 0.001644 −1.30 1.03 1.49 Dynlt1-ps1 dynein light chain Tctex-type 1, pseuodogene 1///dynein light chain Tctex-type 1A
NM_010731 4.38E-04 −1.91 1.12 1.49 Zbtb7a zinc finger and BTB domain containing 7a
NM_144879 5.83E-04 −1.21 1.30 1.42 Vash2 vasohibin 2
NM_146244 4.96E-05 −1.15 1.32 1.36 Rps6kl1 ribosomal protein S6 kinase-like 1
NM_022033 0.004434 −1.30 1.22 1.35 Oxct2a 3-oxoacid CoA transferase 2A
NM_203320 0.005966 5.21 1.32 −1.81 Cxcl3 chemokine (C-X-C motif) ligand 3
NM_010861 0.005792 1.09 −3.33 −1.76 Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow
NM_010780 6.16E-04 1.36 −1.15 −1.47 Cma1 chymase 1, mast cell
XM_006504243 0.00933 1.42 −1.26 −1.47 Tmem156 transmembrane protein 156
NM_019514 6.26E-04 1.35 −1.16 −1.43 Astn2 astrotactin 2
NM_201638 0.002129 1.18 −1.41 −1.40 Mettl14 methyltransferase like 14
NM_009140 0.003614 2.65 1.24 −1.27 Cxcl2 chemokine (C-X-C motif) ligand 2
NM_019810 0.006028 1.88 1.23 −1.36 Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1
NM_009100 0.008386 1.59 −1.09 −1.35 Rptn repetin
NM_001099774 0.008755 1.08 −1.63 −1.13 Krtap17-1 keratin associated protein 17-1
NM_009162 3.89E-06 1.18 −1.48 −1.12 Scg5 secretogranin V

¶Fold difference of lung gene expression between Gsr-WT and Gsr-KO mice at PND56 after neonatal hyperoxia exposure (negative values indicate lower expression in hyperoxia-PND56 Gsr-KO than in hyperoxia-PND56 Gsr-WT, positive values indicate higher expression in hyperoxia-PND56 Gsr-KO than in hyperoxia-PND56 Gsr-WT). Full lists of the Gsr-dependently varied lung genes during recovery after neonate hyperoxia exposure (n=491, 2-way ANOVA p < 0.01) are in Supplementary Table S8.

a

Fold change in PND56 lung after neonate-hyperoxia exposure compared to neonate-air exposure in each genotype (negative values indicate decreased expression in neonate hyperoxia-exposed lung than in neonate air-exposed lung, positive values indicate increased expression in neonate hyperoxia-exposed lung than in neonate air-exposed lung).