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. 2020 Nov 19;38:101804. doi: 10.1016/j.redox.2020.101804

Fig. 5.

Fig. 5

Time-course of mean QSM values in the contrast enhancing region of tumors (A) and normal tissue (B) of subjects receiving P-AscH- show a persistent change in tumors post P-AscH-. QSM post-P-AscH- infusion is decreased by 1.3 ppb (p = 0.001) compared to baseline (approximately 4 h post baseline scan and 30 min post infusion) and remains elevated (1.2 ppb, p = 0.009) post-radiotherapy (approximately 8 h post baseline scan and 3.5 h post infusion). Normal tissue showed no significant change post-P-AscH- infusion (−0.28 ppb, p = 0.65) or post radiation therapy (−0.19, p = 0.39). (C) Shows the differences between mean changes observed in the contrast enhancing region of tumors and normal tissue. Contrast enhancing region of tumors were contoured on a contrast-enhanced T1 image by a board-certified radiation oncologist. Data are normalized per subject to the baseline scan.