Table 5.
Effect of NHF20 and NHF50 on sympatho-vagal balance and haemodynamic parameters in awake NMD patients during daytime
| Baseline | NHF 20 | p1) | NHF 50 | p1) | NIV | p1) | p2) | |
|---|---|---|---|---|---|---|---|---|
| Well-being score (10–0) | 8.1 ± 1.7 | 6.2 ± 2.4 | 0.01 | 4.6 ± 3.0 | <0.01 | 7.6 ± 1.6 | 0.33 | 0.01& |
| Respiratory parameters | ||||||||
| Mean SpO2, % | 95.0 ± 2.4 | 94.4 ± 2.5 | – | 94.4 ± 3.4 | – | 96.3 ± 1.4 | – | n.s.& |
| Mean ptcCO2, mmHg | 42.1 ± 4.4 | 41.9 ± 4.8 | n.s. | 42.5 ± 5.4 | n.s. | 37.7 ± 3.4 | 0.013 | 0.026& |
| Sympatho-vagal balance parameters | ||||||||
| HFnuRRI, % | 44.9 ± 12.6 | 46.2 ± 15.8 | – | 45.9 ± 17.8 | – | 44.2 ± 15.7 | – | n.s.& |
| LFnuRRI, % | 55.1 ± 12.6 | 53.8 ± 15.8 | – | 54.1 ± 17.8 | – | 55.8 ± 15.7 | – | n.s.& |
| LF/HF RRI | 1.6 ± 0.9 | 1.8 ± 1.5 | – | 1.9 ± 1.6 | – | 1.8 ± 1.1 | – | n.s.& |
| HFnu dBPV, % | 20.0 ± 12.3 | 18.1 ± 7.6 | – | 16.8 ± 6.4 | – | 19.8 ± 8.2 | – | n.s.& |
| LF nudBPV, % | 41.4 ± 12.8 | 42.2 ± 10.7 | – | 43.1 ± 10.1 | – | 41.8 ± 11.0 | – | n.s.& |
| LF/HF dBPV | 3.3 ± 3.0 | 3.2 ± 2.9 | – | 3.4 ± 2.6 | – | 2.6 ± 1.5 | – | n.s.& |
| BRS slope | ||||||||
|
Up event count, n ^ Up event count, n ^ |
13.6 ± 10.9 13.6 ± 10.9 |
15.1 ± 10.3 15.1 ± 10.3 |
– |
17.0 ± 12.1 17.0 ± 12.1 |
– |
10.2 ± 8.5 10.2 ± 8.5 |
– | n.s.& |
| Up events, ms/mmHg | 13.8 ± 8.1 | 19.8 ± 13.1 | – | 19.4 ± 17.3 | – | 17.0 ± 18.6 | – | n.s.& |
| Down event count, n ^ | 14.4 ± 10.5 | 18.8 ± 14.6 | – | 17.9 ± 9.7 | – | 13.3 ± 10.8 | – | n.s.& |
| Down events, ms/mmHg | 15.1 ± 7.6 | 17.6 ± 10.2 | – | 18.9 ± 14.9 | – | 17.6 ± 13.4 | – | n.s.& |
| Haemodynamic parameters | ||||||||
| Heart rate, min−1 | 70.2 ± 9.0 | 66.4 ± 8.2 | – | 65.7 ± 9.6 | – | 65.8 ± 8.8 | – | n.s.& |
| Systolic BP, mmHg | 115.4 ± 12.8 | 110.4 ± 12.4 | – | 111.5 ± 18.9 | – | 107.7 ± 17.7 | – | n.s.& |
| Diastolic BP, mmHg | 73.1 ± 9.6 | 71.5 ± 10.4 | – | 72.8 ± 14.1 | – | 69.9 ± 15.6 | – | n.s.& |
| Stroke volume index, mL/m2 | 37.5 ± 10.8 | 37.6 ± 9.5 | – | 37.0 ± 9.3 | – | 36.9 ± 9.0 | – | n.s.& |
| Cardiac index, L/min/ m2 | 2.5 ± 0.7 | 2.5 ± 0.6 | – | 2.4 ± 0.5 | – | 2.4 ± 0.5 | – | n.s.& |
| TPRI, dyne·s m2 cm−5 | 3006.4 ± 978.8 | 2932.8 ± 929.1 | – | 3027.5 ± 886.6 | – | 2918.3 ± 907.7 | – | n.s.& |
Values are depicted as mean and standard deviation or median (interquartile range) for sleep segment of 10-min duration taken from stable N2 sleep with sinus rhythm. Post hoc t tests were not performed when results of multigroup comparisons were non-significant
NHF nasal high flow, NIV non-invasive ventilation, BRS slope slope of baroreceptor reflex sensitivity (up events and down events), HFnudBPV high-frequency component of diastolic blood pressure variability, HFnuRRI high-frequency component of heart rate variability, LFnudBPV low-frequency component of diastolic blood pressure variability, LF/HF dBPV relative ratio of low-frequency and high-frequency component of diastolic blood pressure variability, LFnuRRI low-frequency component of heart rate variability, LF/HF RRI relative ratio of low-frequency and high-frequency component of heart rate variability, nu normalised units (normalised for total power spectra), n.s. not statistically significant, TPRI total peripheral resistance index
1)p values for comparison with baseline values (“no treatment”) using the paired test
2)p values for comparison between all groups/variables
&Univariate ANOVA