Summary table

Background/rationale	IBS is a widespread disease with a pathophysiology largely unknown. We investigated the role of an easy to deliver personalized dietary intervention in the reduction of inflammatory markers and IBS symptom severity
Methodology	30 subjects with diagnosis of IBS (according to Rome-IV criteria) whose inflammatory markers and food specific IgG levels were measured at baseline and after 6 weeks of dietary intervention. IBS Symptom severity was monitored at baseline and after 3 and 6 weeks Monitoring was provided in a general practice outpatient setting and nutritional advice was offered remotely via two telephone sessions with a certified nutritionist
Results	BAFF and PAF values did not differ between baseline and end of study, both in compliant (C) and non-compliant (NC) subjects. Food-specific IgG levels significantly decreased only in compliant subjects. IBS-SSS significantly decreased in both groups. Comparing IBS-SSS between week 3 and week 6, only compliant subjects had a significant reduction
What is known about the subject	Chronic systemic Inflammation and dietary habits have been variously linked to IBS symptoms
What does this study add	The identification of a personal food profile and a personalized dietary intervention was able to rapidly reduce both IBS symptoms and food-specific IgG levels in IBS patients, thus providing a simple and effective way of treatment for these patients
Future perspectives	Larger studies with longer follow-up are needed to further evaluate this approach