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Grouping of animals and dose administration chart
| Group | Type of animal | N | Treatment | Dosing frequency | MTX dose (mg/kg) |
|---|---|---|---|---|---|
| 1 | CIA | 4 | NP-MTX | Weekly | 3 |
| 2 | CIA | 4 | MTX | Weekly | 3 |
| 3 | Control (+) | 4 | Saline | Weekly | – |
| 4 | Control (−) | 4 | Saline | Weekly | – |
CIA collagen-induced arthritis, N number of animals per study group, MTX methotrexate, NP-MTX nanoparticulate methotrexate
