Table 3.

Baseline comparisons: intrinsic network spatial comparison between PTSD patients and healthy controls.

Intrinsic Network	Contrast	Brain Region	Cluster Size	MNI Coordinate			t Stat.	Z score	p FWE Peak
				x	y	z
Anterior DMN	All PTSD > Healthy	Anterior Dorsal ACC	1447	8	40	10	7.29	6.25	<0.001
	All PTSD < Healthy	ns
	PTSD Exp > PTSD Sham	ns
	PTSD Exp < PTSD Sham	ns
Posterior DMN	All PTSD > Healthy	Left Precuneus	384	−6	−68	32	4.96	4.57	0.037
	All PTSD < Healthy	ns
	PTSD Exp > PTSD Sham	ns
	PTSD Exp < PTSD Sham	ns
SN	All PTSD > Healthy	Right Anterior Insula/Frontal Operculum	315	36	16	4	6.90	6.00	<0.001
		Right Temporal Pole	10	54	4	−25	5.20	4.76	0.006
		Left Supplementary Motor Cortex	388	−2	16	60	4.91	4.53	0.016
		Left Frontal Operculum/Anterior Insula	31	−50	10	0	4.70	4.36	0.032
	All PTSD < Healthy	ns
	PTSD Exp > PTSD Sham	ns
	PTSD Exp < PTSD Sham	ns

Direct group comparisons of intrinsic network functional connectivity at baseline pre-NFB among patients with PTSD (n = 36) and healthy controls (n = 36) (voxel-wise pFWE < 0.05, k = 10). All PTSD patients were grouped together at baseline and compared to age-matched healthy controls in terms of network connectivity. Additionally, we report here that the PTSD experimental group and PTSD sham-control groups did not different significantly at baseline with regard to network connectivity. Acronyms: DMN = default mode network, SN = salience network, ACC = anterior cingulate cortex, PTSD = posttraumatic stress disorder, PTSD Exp = posttraumatic stress disorder experimental neurofeedback group, PTSD Sham = posttraumatic stress disorder sham-control neurofeedback group.