Fig. 5. pDCs from IFN^low and IFN^high SLE patients have distinct transcriptomic profiles.

a Sorted pDCs from HC (n = 7), At-Risk (n = 4), and SLE (n = 13) were classified according to the expression level of the IFN score described. b Average expression level of IFN score measured in samples described in a. c Expression level of representative ISGs in sorted pDCs from sample groups described in a. d Differentially expressed transcripts in IFN^low SLE pDCs (n = 543), IFN^high SLE pDCs (n = 674), and At-Risk pDCs (n = 114) compared to HC pDCs. e Summary of the Reactome Pathway Enrichment in differentially expressed genes of the pDCs from IFN^low and IFN^high subgroups compared to HC pDCs.