Table 2.
Incidence of HCC in UMHS and PUHSC cohorts before and after SVR (SVR as a time-dependent variable).
| UMHS cohort | PUHSC cohort | Total | HR (95% CI) | P value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients at risk | Patients developed HCC | HCC incidence (per 100 person-year) | Patients at risk | Patients developed HCC | HCC incidence (per 100 person-year) | Patients at risk | Patients developed HCC | HCC incidence (per 100 person-year) | |||
| No cirrhosis group | |||||||||||
| Before SVR | 434 | 8 | 0.7 (0.3–1.4) | 716 | 2 | 0.1 (0.02–0.3) | 1150 | 10 | 0.3 (0.1–0.5) | ||
| After SVR | 294 | 0 | NA | 385 | 0 | NA | 679 | 0 | NA | NA | |
| Total | 434 | 8 | 0.6 (0.3–1.1) | 716 | 2 | 0.1 (0.02–0.3) | 1150 | 10 | 0.2 (0.1–0.4) | ||
| Cirrhosis group | |||||||||||
| Before SVR | 361 | 30 | 3.4 (2.4–4.9) | 138 | 10 | 2.5 (1.3–4.7) | 499 | 40 | 3.1 (2.3–4.3) | 1.0 | |
| After SVR | 164 | 7 | 2.9 (1.4–6.0) | 59 | 1 | 1.6 (0.2–11.5) | 223 | 8 | 2.6 (1.3–5.2) | 0.9 (0.4–1.9) | 0.74 |
| Total | 361 | 37 | 3.3 (2.4–4.5) | 138 | 11 | 2.4 (1.3–4.3) | 499 | 48 | 3.0 (2.3–4.0) | ||
| Overall | |||||||||||
| Before SVR | 795 | 38 | 1.9 (1.4–2.6) | 854 | 12 | 0.4 (0.2–0.7) | 1649 | 50 | 1.0 (0.8–1.3) | 1.0 | |
| After SVR | 458 | 7 | 1.4 (0. 7–2.9) | 444 | 1 | 0.2 (0.03–1.6) | 902 | 8 | 0.8 (0.4–1.7) | 0.8 (0.4–1.6) | 0.53 |
| Total | 795 | 45 | 1.8 (1.3–2.4) | 854 | 13 | 0.4 (0.2–0.7) | 1649 | 58 | 1.0 (0.8–1.3) | ||
HCC Hepatocellular carcinoma, SVR sustained virologic response, HR hazard ratio, NA not applicable.