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. 2020 Dec 1;6:35. doi: 10.1038/s41526-020-00125-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — MSCs were subjected to SMG, and parallel SMG + LIV_DT over 72 h period at the end of 72 h, samples were treated with either LPA (50 µM) or DMSO. Quantitative analysis of confocal images revealed that LPA addition increased nuclear YAP levels by 105%, 67%, and 43% in the CTRL, SMG, and SMG + LIV_DT when compared to DMSO controls. When compared to nuclear YAP intensity of the LPA treatment alone, SMG + LPA and SMG + LIV_DT + LPA samples were 55% and 29% lower, respectively. YAP nuclear levels in SMG + LIV_DT + LPA remained 70% higher than SMG + LPA group. n > 100/grp. Group comparisons were made via Kruskal–Wallis test followed by Tukey multiple comparison, ****p < 0.0001. Error bars represent standard deviation. Scale bar: 10 μm. Full statistical details were provided in Supplementary Tables 8.