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. 2020 Dec 1;10:20981. doi: 10.1038/s41598-020-77640-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Development of mechanical allodynia in different rat strains following SNI. (A–E) 50% paw withdrawal thresholds to von Frey stimulation, calculated by the Dixon Up and Down method, were measured from 10 days prior to surgery until 177 days post-surgery. Dotted line marks day of surgery. Two-way Repeated Measures ANOVA with Bonferroni’s post-hoc test indicates difference between Sham vs. SNI for each time-point; *P < 0.05, **P < 0.01, ***P < 0.001. (F) Mechanical allodynia expressed as AUC in scatter plot format for each animal presented in (A–E). Two-way ANOVA demonstrated significant effects of strain (F [4,75] = 4.86, P = 0.0015), surgery (F [1,75] = 201.4, P < 0.0001) and a strain*surgery-interaction (F [4,75] = 9.895, P < 0.0001). Therefore Bonferroni post hoc testing was performed between individual strain- and surgical-groups, and not just on strain-level. Bonferroni’s post hoc test revealed differences between Sham vs SNI for each strain (NS = Not Significant = P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001), and for SNI-groups between strains (comparison with SD, ⁺P < 0.05; comparison with WKY, ^{^^^}P < 0.001; comparison with F344/Ico, ^#P < 0.05, ^##P < 0.01). Data are presented as mean ± S.E.M.