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. 2020 Dec 1;10:20981. doi: 10.1038/s41598-020-77640-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sucrose preference in different rat strains is minimally affected by SNI. (A–E) Sucrose consumption expressed as a percentage of total fluid consumption as an index of anhedonia. Notice that this parameter is recorded on cage level, not subject level, and therefore N = 5 for SNI-groups, N = 4 for Sham groups. Sucrose consumption was measured on two consecutive test-days, where the sucrose bottle was placed in either the “L” = left or “R” = right side of the cage. Only SD showed significant effects of surgery. Bonferroni’s post comparison test showed significant differences between Sham and SNI-injured animals only on Day 31 post injury, **: P < 0.01. (F) Sucrose consumption expressed compared to body weight for SD, confirmed the decreasing sucrose consumption for SNI compared with Sham. (G) AUC of total amount of sucrose consumption related to body weight. Two-way ANOVA showed significant effect of strain (F [4,45] = 30.891, P < 0.0001), and Bonferroni’s post hoc showed that both the SD- and WKY-strain consumed significantly more than LEW, F344/Ico and F344/Du (P < 0.001), and that F344/Du consumed more than LEW (P < 0.05), as detected pairwise combined for the two surgical groups for each strain. Data are presented as mean ± S.E.M.