Table 1.

Selected Patient-Reported Outcomes Common Terminology Criteria for Adverse Events symptom list and alert logic.

Symptom	Original grade trigger	Revised grade trigger
Anxiety	3 & 4	Removed
Appetite loss	3 & 4	4
Constipation	3 & 4	4
Cough	3 & 4	4
Diarrhea	3 & 4	4
Fatigue	3 & 4	4
Fever	3	4
Headache	3 & 4	4
Insomnia	3 & 4	4
Nausea	3 & 4	4
Numbness or tingling	3 & 4	4
Pain	3 & 4	4
Rash	3	4
Sad feelings	3 & 4	Removed
Shortness of breath	2, 3, & 4	4
Swelling	3 & 4	4
Vomiting	3 & 4	4
Ad hoca	2 & 3	Removed
Inactivity	1	1

^aAfter an ad hoc symptom reporting session, patients are asked, “Would you like your healthcare team to be aware of an ongoing concern?” If the patient chose “no,” a grade 2 alert was created. If the patient chose “yes,” a grade 3 alert was created. There is no way to generate a grade 1 or grade 4 alert from ad hoc reporting.