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. 2020 Nov 20;12(11):3567. doi: 10.3390/nu12113567

Figure 1.

Figure 1

LINE1 methylation in CRC tumor and the 25th percentile of vitamin B12 in CRC patients. Methylation analyses of LINE1 in (a,b) CRC tumor area, (c,d) adjacent tumor-free area, and (e,f) comparison between tumor and tumor-free area, according to the 25th percentile of vitamin B12 (low serum vitamin B12 = 19; high serum vitamin B12 = 61). Methylation percentages are presented as median (interquartile range) (in a,c,e,f) or individual as individual dots (in b,d). Significant differences between the two groups were assessed using the Welch’s two sample test for the (a,c) (* p < 0.05). Paired t-test was performed to compare means between tumor and adjacent tumor-free area for the (e,f) (* p < 0.05). Pearson correlation was used to determine association between LINE1 methylation and serum vitamin B12 in the (b,d). Abbreviations: LINE1: Long interspersed nuclear element-1; r: Correlation coefficient; CRC: Colorectal cancer.