Ab |
antibody |
ABC |
antibodies bound per cell |
ADC |
antibody–drug conjugate |
AML |
acute myeloid leukemia |
BPDCN |
blastic plasmacytoid dendritic cell neoplasm |
CAR-T |
chimeric antigen receptor T cell |
cHL |
classical Hodgkin lymphoma |
DAR |
drug-to-antibody ratio |
DLBCL |
diffuse large B-cell lymphoma |
EC50
|
half-maximal effective concentration |
FACS |
fluorescence-activated cell sorting |
FCS |
fetal calf serum |
hCD45 |
human CD45 |
hIL3RA |
human IL3RA |
HL |
Hodgkin lymphoma |
IC50
|
half-maximal inhibitory concentration |
IGN |
indolinobenzodiazepine pseudodimer |
IL-3 |
interleukin 3 |
IL3RA |
interleukin 3 receptor subunit alpha |
IL3RA-Ab |
IL3RA-targeting antibody |
i.p. |
intraperitoneal(ly) |
i.v. |
intravenous(ly) |
KD |
dissociation constant |
KSP |
kinesin spindle protein |
KSPi |
kinesin spindle protein inhibitor |
MDS |
myelodysplastic syndrome |
MFI |
median fluorescence intensity |
MST |
median survival time |
Papp |
apparent permeability |
PBD |
pyrrolobenzodiazepine |
PBS |
phosphate-buffered saline |
pDCs |
plasmacytoid dendritic cells |
PDX |
patient-derived xenograft |
P-gP |
P-glycoprotein |
Q7D |
once weekly |
Q14D |
every two weeks |
Q21D |
every three weeks |
rrMM |
relapsed refractory multiple myeloma |
s.c. |
subcutaneous(ly) |
siRNA |
small interfering RNA |
SPR |
surface plasmon resonance |