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. 2020 Nov 20;12(11):3464. doi: 10.3390/cancers12113464
Ab antibody
ABC antibodies bound per cell
ADC antibody–drug conjugate
AML acute myeloid leukemia
BPDCN blastic plasmacytoid dendritic cell neoplasm
CAR-T chimeric antigen receptor T cell
cHL classical Hodgkin lymphoma
DAR drug-to-antibody ratio
DLBCL diffuse large B-cell lymphoma
EC50 half-maximal effective concentration
FACS fluorescence-activated cell sorting
FCS fetal calf serum
hCD45 human CD45
hIL3RA human IL3RA
HL Hodgkin lymphoma
IC50 half-maximal inhibitory concentration
IGN indolinobenzodiazepine pseudodimer
IL-3 interleukin 3
IL3RA interleukin 3 receptor subunit alpha
IL3RA-Ab IL3RA-targeting antibody
i.p. intraperitoneal(ly)
i.v. intravenous(ly)
KD dissociation constant
KSP kinesin spindle protein
KSPi kinesin spindle protein inhibitor
MDS myelodysplastic syndrome
MFI median fluorescence intensity
MST median survival time
Papp apparent permeability
PBD pyrrolobenzodiazepine
PBS phosphate-buffered saline
pDCs plasmacytoid dendritic cells
PDX patient-derived xenograft
P-gP P-glycoprotein
Q7D once weekly
Q14D every two weeks
Q21D every three weeks
rrMM relapsed refractory multiple myeloma
s.c. subcutaneous(ly)
siRNA small interfering RNA
SPR surface plasmon resonance