Table 2. Demographics, Microbiology, and Clinical Outcomes of Patients With Invasive Meningococcal Disease Included in the Analysis in a Study of the Association of a Meningococcus Group B Vaccine With Group B Invasive Meningococcal Disease Among Children in Portugal.
| Characteristic | No. (%) | ||||
|---|---|---|---|---|---|
| Cases with group B disease aged ≥134 d (primary analysis; n = 69)a | Cases with any invasive meningococcal disease aged ≥134 d (n = 85)a | Cases with group B disease aged ≥74 d (n = 82)a | Cases with any invasive meningococcal disease aged ≥74 d (n = 98)a | ||
| Age, median (IQR), mo | 24.1 (10.1-50.1) | 24.1 (9.6-51.3) | 17.5 (6.2-43.6) | 17.5 (7.1-48.5) | |
| Sex | |||||
| Male | 42 (60.9) | 54 (63.5) | 49 (59.8) | 61 (62.2) | |
| Female | 27 (39.1) | 31 (36.5) | 33 (40.2) | 37 (37.8) | |
| Diagnosisb | |||||
| Septicemia and meningitis | 32 (46.4) | 33 (38.8) | 38 (46.3) | 39 (39.8) | |
| Meningitis | 16 (23.2) | 23 (27.1) | 20 (24.4) | 27 (27.6) | |
| Septicemia | 14 (20.3) | 19 (22.4) | 16 (19.5) | 21 (21.4) | |
| Bacteremia | 6 (8.7) | 8 (9.4) | 7 (8.5) | 9 (9.2) | |
| Arthritis | 1 (1.4) | 2 (2.4) | 1 (1.2) | 2 (2.0) | |
| Duration of admission, median (IQR), d | 8 (7-10) | 7 (6-10) | 8 (7-10) | 7 (7-10) | |
| Outcomec | |||||
| Alive with no sequelae | 49 (71.0) | 64 (75.3) | 60 (73.2) | 75 (76.5) | |
| Alive with sequelae | 15 (21.7) | 15 (17.6) | 16 (19.5) | 16 (16.3) | |
| Developmental delay | 9 (13.0) | 9 (10.6) | 10 (12.2) | 10 (10.2) | |
| Death | 5 (7.2) | 6 (7.1) | 6 (7.3) | 7 (7.1) | |
| Amputation | 4 (5.8) | 4 (4.7) | 4 (4.9) | 4 (4.1) | |
| Deafness | 1 (1.4) | 1 (1.2) | 1 (1.2) | 1 (1.0) | |
| Other | 1 (1.4) | 1 (1.2) | 1 (1.2) | 1 (1.0) | |
| Meningococcal capsular groupd | |||||
| B | 69 (100) | 69 (81.2) | 82 (100) | 82 (83.7) | |
| Y | 0 | 11 (12.9) | 0 | 11 (11.2) | |
| W | 0 | 4 (4.7) | 0 | 4 (4.1) | |
| Z | 0 | 1 (1.2) | 0 | 1 (1) | |
Abbreviation: IQR, interquartile range.
a
The youngest valid age for partial vaccination was 74 days and for full vaccination was 134 days.
b
Diagnoses at hospital discharge were options provided on the case report forms to reporting clinicians without strict definition. Twelve children and adolescents were transferred from secondary to tertiary care facilities.
c
Outcomes were extracted from the medical records accessed at the time of data collection, so they reflect information obtained both during admission and follow-up.
d
Meningococcal capsular grouping was done by polymerase chain reaction, as recommended by the World Health Organization.14