Figure 3. Identification of Biomarkers Showing the Strongest Association Using a Combination of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) in Patients With Active Tuberculosis.

Combination of receiver operating characteristic (ROC) model analysis shows the MMP/TIMP signatures that exhibited the highest accuracy in discriminating cases and controls. ROC curves for comparing multiple markers and their combinations between cases vs controls in the test cohort (A) and validation cohort (B) are shown. AUC indicates area under the curve; Combo, Combi ROC (receiver operating characteristic).