Table 2. Association of the Baseline MMP and TIMP Levels With Treatment Outcomes.
| Marker | Univariate model | Multivariable model | ||
|---|---|---|---|---|
| OR (95% CI) | P value | aOR (95% CI)a | P value | |
| MMP-1 | 1.36 (1.01-1.85) | .04 | 1.32 (0.95-1.84) | .10 |
| MMP-2 | 2.76 (1.40-5.48) | .004 | 3.26 (1.51-7.03) | .003 |
| MMP-3 | 0.48 (0.27-0.88) | .02 | 0.45 (0.22-0.92) | .03 |
| MMP-7 | 1.75 (1.18-2.61) | .006 | 1.71 (1.09-2.68) | .02 |
| MMP-8 | 2.04 (1.33-3.14) | .001 | 2.16 (1.34-3.47) | .001 |
| MMP-9 | 1.80 (0.89-3.64) | .10 | 2.16 (0.99-4.67) | .051 |
| MMP-12 | 1.15 (0.30-4.41) | .84 | 1.29 (0.30-5.50) | .73 |
| MMP-13 | 0.20 (0.02-2.39) | .20 | 0.18 (0.01-2.77) | .22 |
| TIMP-1 | 7.55 (2.85-19.9) | <.001 | 8.23 (2.92-23.22) | <.001 |
| TIMP-2 | 12.50 (3.98-41.82) | <.001 | 14.31 (3.83-53.39) | <.001 |
| TIMP-3 | 0.94 (0.29-3.02) | .92 | 0.75 (0.23-2.47) | .64 |
| TIMP-4 | 1.01 (0.62-1.63) | .98 | 1.00 (0.59-1.70) | >.99 |
Abbreviations: aOR, adjusted odds ratio; MMP, matrix metalloproteinase; OR, odds ratio; TIMP, tissue inhibitor of matrix metalloproteinases.
a
Multivariable conditional logistic regression models were used to study the association of biomarker with treatment outcomes (unfavorable) and are adjusted for age in years, sex, body mass index, diabetes status, smoking status, alcohol status, and smear grading.