Table 1.
Complement regulators. The complement system is well regulated at different steps by various soluble or membranous proteins.
| Regulated Steps | Regulators | Soluble or Membranous |
|---|---|---|
| C1 complex/MBL complex | C1 inhibitors | Soluble |
| C3 convertases C5 convertases |
Factor H (FH) | Soluble |
| CFHRs (1 to 5) | Soluble | |
| Properdin (FP) | Soluble | |
| C4 Binding Protein (C4BP) | Soluble | |
| Factor I (FI) | Soluble | |
| Membrane cofactor proteins (MCP/CD46) | Membranous | |
| Decay acceleration factor (DAF/CD55) | Membranous | |
| Complement receptor 1 (CR1) | Membranous | |
| MAC | CD59 | Membranous |
| Clusterin | Soluble | |
| Vitronectin | Soluble |