Figure 1.

Clinical trials for solid tumors: (a) Comparison of number of clinical trials with TcEs, CAR-Ts and CPIs for solid tumors over time (2000, 2010, 2020). The numbers are from a search in the Citeline database by: (1) Mechanism of action: “CD3 agonism” for TcEs and “immune Checkpoint Inhibitors” for CPIs; (2) Therapeutic area: in both cases, “Oncology”, and as sub-categories all listed solid tumor indications; (3) Therapeutic modality: monoclonal antibodies and all similar classes (chimeric, humanized, human); (4) Timeframe: before year 2000, between years 2000 and 2010, and in year 2020; (b) Percent of clinical trials for solid tumor indications vs. all oncology indications for each of the three therapeutic modalities. The numbers inside the columns correspond to the number of clinical trials. The percent number on the side of each column indicates the percent of clinical trials for solid tumor indications vs. for all oncology indications with each of these therapeutic modalities.