Table 2.
Laboratory and microbiological findings of enrolled patients with active and subclinical TB disease
| Variables | All patients (n = 420) | Active TB disease (n = 339) | Subclinical TB disease (n = 81) | p value |
|---|---|---|---|---|
| Initial AFB smear test result | ||||
| Positive | 116 (23.6–32.1%) | 105 (26.3–36.1%) | 11 (15.2–7.5%) | |
| Negative | 304 (67.9–76.4%) | 234 (63.9–73.7%) | 70 (77.3–92.2%) | |
| Initial AFB culture test result | ||||
| Positive | 289 (64.2–73.1%) | 245 (67.3–76.8%) | 44 (43.5–64.7%) | |
| Negative | 131 (26.9–35.8%) | 94 (23.2–32.7%) | 37 (35.3–56.5%) | |
| Initial NAAT resulta | ||||
| Positive | 264 (60.7–70.0%) | 228 (65.0–74.9%) | 36 (35.5–57.1%) | |
| Negative | 139 (30.0–39.3%) | 97 (25.1–35.0%) | 42 (42.9–64.5%) | |
| Drug susceptible testa | ||||
| Susceptible to both INH and RIF | 249 (82.7–90.5%) | 212 (82.5–90.9%) | 37 (72.7–93.4%) | |
| Resistant to either INH or RIF | 37(9.5–17.3%) | 31 (9.1–17.5%) | 6 (6.6–27.3%) | |
| Inflammatory markersb | ||||
| White blood cell count (mm3) | 6970 ± 4084 | 7707 ± 3283 | 6137 ± 2626 | 0.000 |
| Neutrophil (%) | 58.6 ± 24.4 | 65.9 ± 16.2 | 58.2 ± 19.4 | 0.000 |
| Lymphocyte (%) | 22.5 ± 11.1 | 21.3 ± 11.2 | 26.7 ± 9.2 | 0.000 |
| Platelet count (mm3) | 248,368 ± 135,229 | 282,861 ± 122,293 | 225,926 ± 95,965 | 0.000 |
| C-reactive protein (mg/dL) | 2.7 ± 4.9 | 3.5 ± 5.2 | 0.5 ± 1.5 | 0.000 |
| Haemoglobin (g/dL)c | ||||
| All participants | 12.7 ± 1.9 | 12.6 ± 1.9 | 13.5 ± 1.9 | 0.000 |
| Male | 13.2 ± 2.1 | 13.1 ± 2.0 | 14.2 ± 1.8 | 0.001 |
| Female | 12.0 ± 1.5 | 11.9 ± 1.4 | 12.4 ± 1.3 | 0.087 |
Values were expressed as numbers with 95% confidence intervals of their proportion
TB tuberculosis, AFB acid-fast bacilli, NAAT nucleic acid amplification test, INH isoniazid, RIF rifampicin
aUnknown data are regarded as missing
bMann–Whitney U test was conducted for white blood cell count, neutrophil, lymphocyte, platelet count, and C-reactive protein
cStudent’s t test was conducted for haemoglobin