Table 2.
ER stress-regulated lncRNAs and their potential mechanisms in cancers
| LncRNAs | Expression level | Tumor type | UPR-related mechanism | Biological process | References |
|---|---|---|---|---|---|
| GOLGA2P10 | Upregulated | HCC | CHOP can directly bind to the GOLGA2P10 promoter | Induces resistance to cytotoxic effect of ER stress | [26] |
| MALAT1 | Upregulated | Colorectal cancer | Activated IRE1 and PERK signaling pathways increase MALAT1expression | Promotes the migration of CRC cells | [87] |
| MIAT | Upregulated | Breast cancer | Overexpression of GRP78 upregulates the expression of MIAT by increasing OCT4 in 5-fluorouracil resistant cells | Contributes to 5-FU resistance | [175] |
HCC, hepatocellular carcinoma