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. 2020 Dec 1;18:177. doi: 10.1186/s12951-020-00734-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — In vitro characterization of Her2 tumor-targeting properties of the functionalized silk particles. a Flow cytometry analysis of the binding of silk spheres to the cancer cells. Murine Her2-overexpressing cells (D2F2E2/LUC) and control Her2-negative cells (D2F2/LUC) were incubated with spheres made of functionalized (H2.1MS1) or control (MS1) silks conjugated with a fluorophore (ATTO647N) and then analyzed cytometrically. b Doxorubicin loading into silk particles. The amount of Dox incorporated into the MS1 and H2.1MS1 spheres are presented. c Cytotoxicity study by the MTT assay. Her2-overexpressing (D2F2E2/Luc) cells and control cells (D2F2/Luc) were cultured in the presence of the silk spheres loaded with Dox (MS1 or H2.1MS1). The percentage of the MTT reduction was calculated in reference to non-treated control cells. The results are expressed as the mean of three independent experiments ± SEM. (**) indicates statistical significance with p < 0.01 and (***) p < 0.001