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. 2020 Dec 1;18:177. doi: 10.1186/s12951-020-00734-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Representative images indicating the biodistribution of functionalized silk spheres in Her2(+) and Her2(−) mouse orthotopic breast cancer models. Biodistribution of H2.1MS1 spheres over time after intravenous injection of BALB/c mice, which developed a Her2(−) D2F2 tumors and b Her2(+) D2F2E2 tumors. Biodistribution of c H2.1MS1 spheres and d Herceptin 48 and 168 h after the 3rd intravenous injection in mice that developed D2F2E2 tumors. Organs and tumors were excised and imaged. Signal detection was performed by using the IVIS Spectrum system to estimate the luminescence intensity of the tumors and the fluorescence intensity of the ATTO647N-labeled H2.1MS1 spheres and Herceptin at wavelengths of 640/680 nm