Table 2.
Comparison of basic indicators of WKY and SHR groups
| Indexs | WKY(n = 6) | SHR(n = 6) | P |
|---|---|---|---|
| Body weight, g | 251.06±12.70 | 246.78±5.32 | 0.78 |
| Noninvasive measure | |||
| Systolic blood pressure, mm Hg | 121.10±6.56 | 207.66±14.12 | 0.001 |
| Heart rate, bpm | 370.66±20.04 | 409.66±47.19 | 0.030 |
| Diastolic measures | |||
| Peak early diastolic LV filling velocity | 708.2±6.52 | 702±11.39 | 0.318 |
| Peak E and A velocity ratio | 2.03±0.12 | 1.55±0.08 | 0.014 |
| E/E’ | 20.25±0.62 | 22.67±0.92 | 0.001 |
| E’/ A’ | 1.58±0.23 | 0.86±0.02 | <0.001 |
| Systolic measures | |||
| Fraction shortening, % | 40.65±0.24 | 41.65±0.93 | NS |
| Ejection fraction, % | 74.63±0.38 | 75.86±1.03 | NS |
| LV dimensions | |||
| LV posterior wall thickness, mm | 1.26±0.08 | 1.37±0.02 | 0.014 |
| LV end-diastolic dimension, mm | 6.03±0.03 | 6.04±0.05 | NS |
| Invasive measure | |||
| Heart rate | 342.67±47.11 | 382.56± 46.05 | 0.025 |
| Systolic function | |||
| Max LV systolic pressure | 101.55 ±4.64 | 146.60±11.29 | 0.001 |
| dP/dtmax, mm Hg/s | 6344.01±1744.84 | 7975.70±1434.87 | 0.09 |
| Diastolic function | |||
| LV end-diastolic pressure | 11.92± 5.94 | 51.64±14.96 | 0.001 |
| dP/dtmin,mm Hg/s | -4258.06±375.55 | -6299.40±1192.38 | 0.001 |
| dP/dtmin/LVSP | -49.17±6.60 | -38.19±5.62 | 0.004 |
| Time constant of isovolumic LV relaxation | 18.51±3.35 | 25.9±3.38 | 0.001 |
Notes: Values are mean ± SD. NS means the difference was not statistically significant. A: Peak late diastolic LV filling velocity; E: Peak early diastolic LV filling velocity; E’and A’: Maximal velocity of mitral annulus during early and late diastole, LV: Left ventricle; LVSP: LV systolic pressure; SHRs: Spontaneously hypertensive rats, WKY: Wistar-Kyoto rats