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. 2020 Dec 1;17:367. doi: 10.1186/s12974-020-02038-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Blood-brain barrier breakdown after BCAS is exacerbated by Nrf2 deficiency. a There were no significant alterations in IgG levels in the corpus callosum. b There was a significant effect of surgery and genotype on IgG levels in the internal capsule, with Nrf2^−/− displaying highest density of IgG. (Double asterisk indicates post hoc significant difference between sham and BCAS Nrf2^−/− mice, double number sign and number sign indicate a difference between Nrf2^−/− BCAS and wild type or Nrf2^+/− BCAS groups respectively) c There was a significant increase in IgG levels in the optic tract with BCAS surgery (asterisk indicates post hoc significant difference between sham and BCAS Nrf2^−/− mice). Mean ± SEM. **p < 0.01, #p < 0.05, ##p < 0.01. d Representative images of IgG staining in the optic tract, brown stain depicts IgG, blue is haematoxylin counterstain. Scale bar 50 μm