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. 2020 Dec 1;17:365. doi: 10.1186/s12974-020-02031-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — NF-KB inhibition in microglia leads to white matter volume preservation. MRI volumetric analysis at postnatal day 15 comparing sham RA, HI IKKβ^flox/wt CSF-1R Cre− (HI Cre−), and HI IKKβ^flox/wt CSF-1R Cre+ (HI Cre+), using the BioSpec 94/30 imaging system is a 9.4 T horizontal bore magnet operates at 400 MHz and runs ParaVision™4.0 software. a Coronal (top) and axial (bottom) brain slices. b The two lateral ventricle volumes measured by paravision software. c Total brain volume includes brain volume + lateral ventricle volume measured by paravision software. d The ratio of both lateral ventricle volumes to total brain volume measured by paravision software. N = 10 animals/group. Scatter dot plot showing mean ± SE. indicates*P < 0.05. **P ≤ 0.01