Fig. 4.
NF-KB inhibition in microglia rescues oligodendroglia in HI model. a CNPase in red (early oligodendroglia differentiation marker) in the periventricular area of RA, HI IKKβflox/wt CSF-1R Cre− (HI Cre−), and HI IKKβflox/wt CSF-1R Cre+ (HI Cre+) at postnatal day 15. Quantification of CNPase intensity as fold change where sham = 1. b Olig 2 in red (early oligodendroglia transcription factor) in the periventricular area of RA, HI IKKβflox/wt CSF-1R Cre− (HI Cre−), and HI IKKβflox/wt CSF-1R Cre+ (HI Cre+) at postnatal day 15. Quantification of Olig2-positive cells per section. Scale bar = 100 μm N = 5 animals/ group. Four sections/animal. Scatter dot plot showing mean ± SE. *P < 0.05. **P ≤ 0.01. ***P ≤ 0.001, ****P ≤ 0.0001