Table 3.
Liver/kidney function related biomarkers in dairy cows with LDA or healthy cows
| Detected biomarkers | Control | LDA | p | ||
|---|---|---|---|---|---|
| Mean±SEM | 95% CI | Mean±SEM | 95% CI | ||
| ALT (U/L) | 19.20±1.42 | 16.82-21.57 | 23.20±1.16** | 20.82-25.57 | 0.000 |
| AST (U/L) | 86.65±3.18 | 80.00-93.29 | 122.87±6.65** | 109.27-136.46 | 0.000 |
| AST/ALT | 4.48±0.26 | 3.92-5.03 | 6.70±0.35** | 5.98-7.42 | 0.000 |
| GGT (U/L) | 23.20±2.56 | 20.33-25.87 | 32.07±2.22** | 28.52-35.61 | 0.015 |
| LDH (U/L) | 850.37±63.5 | 744.05-956.68 | 950.37±51.92* | 844.05-1056.68 | 0.015 |
| TBIL (μmol/L) | 4.07±0.5 | 3.02-5.11 | 6.30±0.52** | 5.23-7.37 | 0.002 |
| DBIL (μmol/L) | 1.54±0.19 | 1.13-1.95 | 2.48±0.22** | 2.02-2.94 | 0.001 |
| IBIL (μmol/L) | 2.53±0.31 | 1.87-3.18 | 3.82±0.34* | 3.13-4.51 | 0.010 |
| TP (g/L) | 76.05±1.35 | 73.23-78.87 | 68.74±1.81** | 65.04-72.43 | 0.040 |
| ALB (g/L) | 33.78±0.66 | 32.38-35.16 | 27.35±0.67* | 25.98-29.71 | 0.005 |
| GLO (g/L) | 42.27±1.41 | 39.31-45.22 | 39.39±1.55 | 36.21-42.56 | 0.201 |
| BUN (mmol/L) | 4.61±0.3 | 3.99-5.23 | 6.20±0.52* | 5.14-7.26 | 0.040 |
| Creatinine (mmol/L) | 63.00±2.12 | 58.55-67.45 | 79.03±3.4** | 72.07-85.99 | 0.001 |
The Liver/kidney function related biomarkers of dairy cows with LDA or healthy cows (Control) were shown in the table. Healthy Holstein cows, n = 20; LDA Holstein cows, n = 30. The results are expressed as the mean ± SEM. *P < 0.05, **P < 0.01, compared with respective values in control (healthy) group
ALT Alanine aminotransferase, AST Aspartate aminotransferase, GGT γ glutamyl transpeptidase, LDH Lactate dehydrogenase, TBIL Total bilirubin, DBIL Direct bilirubin, IBIL Indirect bilirubin, TP Total protein, ALB Albumin, GLO Globulin, BUN Blood urea nitrogen