Table 5.
AUC, sensitivity and specificity of potential biomarkers for LDA identification
| Energy metabolism biomarkers | Liver/kidney function biomarkers | Minerals | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NEFA | BHBA | INS | GC | RQUICKI | ALT | AST | GGT | LDH | TBIL | DBIL | IBIL | TP | ALB | BUN | Creatinine | Cl | Ca | K | |
| AUC | 0.84 | 0.75 | 0.89 | 0.73 | 0.89 | 0.89 | 0.84 | 0.88 | 0.71 | 0.75 | 0.74 | 0.73 | 0.73 | 0.82 | 0.7 | 0.86 | 0.81 | 0.94 | 0.78 |
| Se | 0.77 | 0.8 | 0.87 | 0.73 | 0.83 | 0.87 | 0.7 | 0.87 | 0.77 | 0.73 | 0.73 | 0.67 | 0.43 | 0.87 | 0.87 | 0.97 | 0.63 | 0.90 | 0.70 |
| Sp | 0.9 | 0.65 | 0.85 | 0.65 | 0.85 | 0.85 | 0.95 | 0.75 | 0.6 | 0.8 | 0.75 | 0.85 | 0.95 | 0.7 | 0.5 | 0.7 | 0.95 | 0.95 | 0.75 |
| Cp |
0.68 mM |
0.75 mM |
10.4 mU/L |
58.6 ng/L |
0.68 |
19.5 U/L |
106 U/L |
24.5 U/L |
812 U/L |
4.85 μM |
1.65 μM |
2.95 μM |
67.6 μM |
33.0 μM |
5.34 mM |
74 mM |
98 mM |
2.25 mM |
4.05 mM |
Each evaluated variable of the potential biomarkers, including area under the curves (AUCs), sensitivity, specificity, or cut-point, was calculated and shown in the table. Youden Index (YI)was calculated as YI = Sensitivity- (1-specificity). A cut-point for each parameter was chosen when a maximum YI was detected
Se Sensitivity, Sp Specificity, Cp Cut point, NEFA Non-esterified fatty acid, BHBA β-hydroxybutyric acid, INS Insulin, GC Glycagon, RQUICKI Revised quantitative insulin sensitivity check index, ALT Alanine aminotransferase, AST Aspartate aminotransferase, GGT γ glutamyl transpeptidase, LDH Lactate dehydrogenase, TBIL Total bilirubin, DBIL Direct bilirubin, IBIL Indirect bilirubin, TP Total protein, ALB Albumin, BUN Blood urea nitrogen