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. 2020 Dec 2;20:1180. doi: 10.1186/s12885-020-07660-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Enhanced LAD1 expression is associated with metastatic colorectal cancer tissues. a, b LAD1 expression was enriched in colorectal cancer (CRC) tissues compared with normal tissues. Staining intensities of anti-LAD1 antibody in colorectal cancer tissues were stratified into 4 categories (negative, weak, moderate, and strong; A). Strongly stained tissues were detected only in CRC (n = 35) and not in normal controls (n = 9; b). c, d Strong LAD1 staining was observed only in CRC tissues and not in the matched normal tissues (n = 7). Representative images of LAD1 immunohistochemistry and the proportion of differentially stained LAD1 tissues are shown in (c) and (d), respectively. e, f Comparison of matched primary and metastatic CRC tissues (e) showed a higher proportion of strong LAD1 staining intensities in metastatic tissues (n = 9; f)