Fig. 2.

Annotation of all CpGs and DMCs in all the genomic regions and their DNA methylation levels. a Distribution (%) of annotated genomic regions among all CpGs (hatched bars) and among DMCs including hypoDMCs (black bars) and hyperDMCs (gray bars). Occurrence of DMCs (hypo and hyperDMCs) and hypoDMCs in each region was assessed using Fisher’s exact test and p < 0.001 was marked with * and †, respectively. b Average methylation levels of all CpGs in the individual genomic regions. c Box-and-whisker plots of methylation levels of hypo/hyperDMCs in the individual genomic regions. Crosses and bars in the box represent average and median values, respectively, and dots indicate outliers