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. 2020 Dec 2;13:53. doi: 10.1186/s13072-020-00375-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — ChrX and ChrY were enriched with IAPE hypoDMCs and with L1MdA and L1MdF hypoDMCs, respectively. All CpGs and hypoDMCs in chrY and chrX in all the genic region were annotated according to the detailed annotation of HOMER. The detailed annotations were grouped as shown in Additional file 1: Table S1B. Percentage among CpGs (hatched bars) and hypoDMCs (black bars) were shown for chrX and chrY, respectively. # promoter indicates promoter-TSS and 5′UTR. Occurrence of hypoDMCs in each region was assessed using Fisher’s exact test and p < 0.01 was marked with *