Table III.

Univariate and multivariate Cox analyses of overall survival of patients with non-small cell lung cancer.

	Univariate Cox analysis of survival				Multivariate Cox analysis of survival
Characteristics	P-value	Hazard ratio	95% CI lower	95% CI upper	P-value	Hazard ratio	95% CI lower	95% CI upper
p63 (negative vs. positive)	0.7645	1.0680	0.6945	1.6424
TTF-1 (negative vs. positive)	0.8613	1.0484	0.6168	1.7822
Histological type (adeno vs. SCC)	0.1486	0.7301	0.4765	1.1187
Clinical stage (I–II vs. III–IV)	0.0003	1.5542	1.2215	1.9775	0.6312	1.1109	0.7231	1.7064
pT (pT1-2 vs. pT3-4)	0.0024	1.5170	1.1593	1.9852	0.0061	1.7928	1.1809	2.7216
pN (pN0 vs. pN1-3)	0.0023	1.9072	1.2604	2.8861	0.0068	1.4608	1.1105	1.9216
Necrosis (%) (continuous)	0.3824	0.9458	0.8347	1.0718
Histological grade (G1 vs. G2-3)	0.1886	1.3095	0.8761	1.9572
Tesmin IRS (0 vs. 1–12)	0.1184	3.0555	0.7521	12.4124
Tesmin nuclear (0 vs. 1–4)	0.3831	1.2978	0.7225	2.3310
MCM-5 (0–2 vs. 3–4)	0.4159	0.8169	0.5019	1.3297
MCM-7 (0–2 vs. 3–4)	0.5114	1.3192	0.5770	3.0160
Ki-67 (0–2 vs. 3–4)	0.8906	0.9641	0.5730	1.6224

IRS, immunoreactive score; MCM, minichromosome maintenance protein; TTF-1, thyroid transcription factor 1; SCC, squamous cell carcinoma of the lung.