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. 2020 Nov 19;21(1):59. doi: 10.3892/ol.2020.12321

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — p53-siRNA abrogates the inhibitory effects of dioscin on A431 cells. (A) A431 cells were transfected with p53-siRNA and the viability of cells was measured. Effects of dioscin and p53-siRNA on (B) cell colony formation ability, (C) cell migration, apoptosis and DNA damage, (D) p53 expression via immunofluorescence and (E) protein expression levels of cleaved-PARP, cleaved caspase-3/9, Bax, Bcl-2, RHO and cdc42. Scale bar, 100 µm. Data are presented as the mean ± SD (n=3). **P<0.01 vs. dioscin group. PARP, poly (ADP-ribose) polymerase; ns, not significant; siRNA, small interfering RNA.