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. 2020 Nov 20;21(1):64. doi: 10.3892/ol.2020.12315

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Copyright: © Kuroki et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Immunohistochemical analysis of HDAC6 and PD-L1 in normal urothelium and UC. (A) HDAC 6 was detected in the cytoplasm of normal urothelium. Staining for HDAC6 was either (B) low or (C and D) high and was detected in the (C) cytoplasm or (D) nucleus and cytoplasm of UC. Membranous staining of PD-L1 was not detected in (E) normal urothelium; however, it was detected in (F) UC cells (indicated by the arrowheads). UC, urothelial cancer; PD-L1, programmed death-ligand 1; HDAC, histone deacetylase.