Table 2.

Animal models used in gene therapy for diseases related to various organ systems.

Animal Models	Organ Systems	References
Murine	Muscular system	[29, 30, 111, 114]
	Circulatory system	[31, 32, 36, 39]
	Cancer	[27, 28]
	Ocular system	[24, 45, 48]
	Nervous system	[33, 53]
	Aging	[52]
Canine	Endocrine system	[74]
	Circulatory system	[60, 61, 63, 64, 67, 68]
	Ocular system	[46, 47, 65, 66, 69]
	Muscular system	[42, 57, 75]
Non-human primates	Ocular system	[86]
	Nervous system	[83, 84]
	Respiratory system	[81, 82]
Humanized mice	Cancer	[95]
	Circulatory system	[88, 89, 92, 94]
	Immune system	[91, 96]
	Hepatobiliary system	[99]
Porcine	Circulatory system	[100, 103, 105]
	Respiratory system	[108]
	Ocular system	[107]
	Muscular system	[118]
Rabbit	Circulatory system	[120, 122]
	Ocular system	[124]
Other models (Feline, Bovine, Equine)	Nervous system	[132]
	Hepatobiliary system	[133]
	Skeletal system	[134]